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Total hip arthroplasty with subtrochanteric osteotomy for severe developmental dysplasia of the hip: A systematic review and meta-analysis
⁎Corresponding author: Tomonori Shigemura. tshigepon@yahoo.co.jp
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Received: ,
Accepted: ,
This article was originally published by Reed Elsevier India Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.
Abstract
Abstract
Total hip arthroplasty (THA) for severe developmental dysplasia of the hip (DDH) is technically difficult because of the anatomical features of dysplasia, such as a hypoplastic and shallow acetabulum, narrow femoral canal, and soft tissue contractures. Subtrochanteric osteotomy (STO) is effective technique to reduce the risk of sciatic nerve palsy while placing the acetabular cup in an anatomical position during THA for severe DDH. Few studies have compared THA performed without STO to THA performed with STO. We performed a systematic literature review and single-arm meta-analysis to integrate the results of studies regarding THA with STO for severe DDH.
A systematic literature review was conducted using relevant original studies from various databases. Pooling of data was performed using RevMan software. A p-value of <0.05 was considered significant. The results are expressed as incidences with 95 % confidence intervals (CIs) for dichotomous data and means with 95 % CI for continuous data. Statistical heterogeneity was assessed based on I2 using the standard χ2 test. When I2 > 50 %, significant heterogeneity was assumed, and a random-effects model was applied for the meta-analysis. A fixed-effects model was applied in the absence of significant heterogeneity.
Twelve studies were included in this meta-analysis. The pooled incidence of sciatic nerve palsy, delayed union or nonunion, dislocation, intraoperative femoral fracture, and infection were 2.44 % (95 % CI: 0.86–4.01), 2.74 % (95 % CI: 1.11–4.37), 2.92 % (95 % CI: 1.63–4.20), 2.19 % (95 % CI: 0.95–3.42), and 3.11 % (95 % CI: 0.10–6.12), respectively. Pooling of the data also showed a mean Harris Hip Score (HHS) of 88.33 (95 % CI: 84.95–91.70).
Although THA with STO for severe DDH is a challenging surgical procedure, this meta-analysis showed that the results of THA with STO for severe DDH are favourable.
Level of evidence: Ⅳ (systematic review and meta-analysis).
Keywords
Total hip arthroplasty
Developmental dysplasia of the hip
Subtrochanteric osteotomy
1 Introduction
Total hip arthroplasty (THA) is one of the most effective treatments for end-stage hip disease.1–4 However, THA for severe developmental dysplasia of the hip (DDH), especially Crowe type IV or Hartofilakidis type C,5,6 is technically difficult because of the anatomical features of dysplasia, such as a hypoplastic and shallow acetabulum,7 narrow femoral canal, an excessive anteversion of the proximal femur, and soft tissue contractures.8,9 Superior placement of the acetabular cup delays the recovery of abductor muscle moments after THA and affects long-term survival; therefore, the cup should be placed at the level of the true acetabulum when performing THA for severe DDH.10–12 Subtrochanteric osteotomy (STO) with bone segment resection is a technique that could reduce the risk of sciatic nerve palsy when placing the acetabular cup in an anatomical position during THA for severe DDH.13 STO is also a good option for adjusting leg length discrepancy.14 However, THA with STO has potential complications, such as delayed union or nonunion of the osteotomy site and intraoperative fractures, in addition to the complications of standard THA, such as dislocation and infection.15
The efficacy and safety of STO are unknown because few studies have compared THA without STO to THA with STO. To address this limitation, we performed a systematic literature review and single-arm meta-analysis to integrate the study results of THA with STO for severe DDH.
2 Materials and methods
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement16 was followed. Ethical approval for this systematic review and meta-analysis was deemed unnecessary as the study did not include individual patient data.
2.1 Search strategy
On the May 26, 2023, we systematically searched PubMed, Web of Science, and the Cochrane Library electronic databases for relevant articles. The following terms were used for our search: “total hip arthroplasty” and “subtrochanteric osteotomy”. We also checked the reference lists in the retrieved articles to include additional studies that met the criteria but had not been identified by the electronic search. All studies identified were individually assessed for inclusion.
2.2 Eligibility criteria
Articles were selected according to the following eligibility criteria: (1) prospective or retrospective study; (2) reporting THA with STO for severe DDH in more than 50 hips; (3) published after 2000; and (4) including data for surgical and clinical outcomes.
Duplicate publications and articles written in languages other than English were excluded. Reviews, letters, comments, meeting proceedings, editorials, practice guidelines, registry studies, and studies reporting insufficient data were considered unsuitable and also excluded.
2.3 Data extraction
Two authors independently scanned the titles and abstracts of all potential articles. Additionally, the full texts of articles that met our inclusion criteria were screened and a final decision was made regarding inclusion/exclusion of the article in our review. Disagreements were resolved through discussion and consensus.
The following data were extracted from selected articles: (1) name of the first author, year of publication, country, and study design; (2) demographic characteristics of the participants including sample size, sex, age, follow-up period, and classification of DDH; and (3) outcomes for the meta-analysis including complications and clinical outcomes, and outcomes for the subanalysis including type of STO, type of femoral stem, surgical approach, and amount of femoral bone resection.
2.4 Outcome measures
The primary outcome was the rate of sciatic nerve palsy, and secondary outcomes were the rate of delayed union or nonunion, dislocation, intraoperative femoral fracture, infection, and clinical score. The clinical score was evaluated using the Harris Hip Score (HHS)17 or a modified version of the score.
2.5 Quality assessment
Two authors independently assessed the quality of the included studies, and any disagreement was resolved through discussion. The Newcastle-Ottawa Scale (NOS)18 was used to evaluate the quality of the study as included studies were single-arm studies. The NOS is a quality assessment tool comprised of three sections (selection, comparability, and exposure or outcome), with rating scores of 0–3, 4–6, and 7–9 indicating poor, fair, and good studies, respectively.
2.6 Statistical analysis
Data were pooled using RevMan software (version 5.3, Cochrane Collaboration, Oxford, UK). A p value < 0.05 was considered statistically significant. The results are expressed as incidences with 95 % confidence intervals (CIs) for dichotomous data and means with 95 % CI for continuous data. Statistical heterogeneity was assessed based on I2 using the standard χ2 test. Significant heterogeneity was assumed, and a random-effects model was applied for the meta-analysis when the evaluation showed I2 > 50 %. A fixed-effects model was used in the absence of significant heterogeneity. For studies that reported continuous variables with ranges instead of standard deviation (SD), we estimated the SD using the Walter method.19 Publication bias was estimated using funnel plots. An asymmetry in the funnel plot suggested the existence of a publication bias.
3 Results
3.1 Search results
A preliminary review of 385 articles sourced from the database searches was conducted. Of those, 132 articles were excluded because of duplication. Among the remaining 253 articles, 190 were excluded after screening the titles and abstracts. Of the remaining 63 articles, 51 were excluded from the meta-analysis following a review of the full text of the article. No articles from the reference review were deemed eligible for inclusion. Following the completion of all screening processes, 12 studies (including a total of 856 THAs)20–31 were eligible for inclusion in the meta-analysis for the assessment of methodological quality. A flowchart of the inclusion process for the articles is shown in Fig. 1.

3.2 Patient characteristics
Among the 12 studies included in this meta-analysis, six studies were performed in Turkey, three in China, and one each in Japan, Norway, and Italy. Further details regarding these studies are summarised in Table 1. In addition, the surgical details for each study are shown in Table 2.
| Authors | Year | Country | Study design | Hips/Patients | Sex (F/M) | Age (years) | Follow-up period (years) | Classification of dysplasia (Crowe Ⅲ/Ⅳ) |
| Fujishiro et al. | 2012 | Japan | retrospective | 70/59 | 58/1 | 62.4 (47-78) | NA | 0/70 |
| Sofu et al. | 2015 | Turkey | retrospective | 73/68 | 60/8 | 47 (31-69) | 5.1 (3-7.7) | 10/63 |
| Desteli et al. | 2015 | Turkey | retrospective | 60/52 | 49/11 | 51.4 ± 13.4 | 6.5 ± 1.7 | 37/23 |
| Zeng et al. | 2017 | China | retrospective | 52/45 | 37/8 | 40.6 (18-62) | 9.8 (8.9-11.8) | 0/52 |
| Wang et al. | 2017 | China | retrospective | 76/62 | 49/13 | 46.5 (19-73) | 10 (6.6-13.2) | 0/76 |
| Vreim Holm et al. | 2019 | Norway | retrospective | 65/46 | 34/12 | 48 (16-79) | 13 (8-18) | NA |
| Grappiolo et al. | 2019 | Italy | retrospective | 102/74 | 57/17 | 53.9 (20-83) | 11.3 (5-25) | 0/102 |
| Karaismailoglu et al. | 2020 | Turkey | retrospective | 51/40 | 37/3 | 44.6 ± 10.4 | 5.7 (5-7.1) | 18/33 |
| Köken et al. | 2020 | Turkey | retrospective | 50/28 | 26/2 | 38.6 ± 11.9 | 7.9 (6.0-9.8) | 0/50 |
| Sun et al. | 2020 | China | retrospective | 62/NA | 55/7 | 41.62 ± 13.34 | NA | 0/62 |
| Sukur et al. | 2022 | Turkey | retrospective | 68/56 | 56/0 | 48.2 (36-64) | 12.9 (5.2-16.8) | 0/68 |
| Ors et al. | 2022 | Turkey | retrospective | 127/91 | 81/10 | 43.0 ± 13.8 | 8.4 (6-10.4) | 0/127 |
| Authors | Type of STO | Femoral stem | Approach | Amount of femoral bone resection (cm) |
| Fujishiro et al. | Transverse | S-ROM (Depuy, Warsaw, Indiana) | Posterior | 2.9 (1.0 - 5.5) |
| Sofu et al. | Transverse | Proximally HA porous-coated fit and fill type | Posterior | Crowe Ⅲ: 3.4 ± 0.5Crowe Ⅳ: 4.7 ± 0.3 |
| Desteli et al. | Transverse | Proximally HA porous-coated fit and fill type | Posterior | NA |
| Zeng et al. | Transverse | S-ROM (Depuy, Warsaw, Indiana) | Posterior | 3.5 ± 0.6 |
| Wang et al. | Transverse | S-ROM (Depuy, Warsaw, Indiana) | Posterior | 2.68 (2.0 - 4.6) |
| Vreim Holm et al. | Step-cut/Oblique | Monoblock straight stem | DL/Posterior | NA |
| Grappiolo et al. | Transverse | Monoblock conical cementless stem | Posterior | 3.3 (2.0 - 5.0) |
| Karaismailoglu et al. | Oblique | Cementless stems | Posterior | NA |
| Köken et al. | Transverse | Cementless Zweymüller | DL | 3 (2 - 4) |
| Sun et al. | Transverse | S-ROM (Depuy, Warsaw, Indiana) | Posterior | NA |
| Sukur et al. | Transverse | Straight cylindrical cementless/modular femoral revision stem | Posterior | 6.7 ± 0.5 |
| Ors et al. | Transverse | Monoblock conical cementless stem | Posterior | 3.2 ± 0.5 |
3.3 Quality assessment
The NOS was used to evaluate the eligibility of the 12 included studies. The articles were scored according to the three sections of the NOS (Table 3).
| Selection | Comparability | Outcome | |
| Fujishiro et al. | ※※ | ※ | ※※ |
| Sofu et al. | ※※ | ※ | ※※ |
| Desteli et al. | ※※ | ※ | ※※ |
| Zeng et al. | ※※ | ※ | ※※ |
| Wang et al. | ※※ | ※ | ※※ |
| Vreim Holm et al. | ※※ | ※ | ※※ |
| Grappiolo et al. | ※※ | ※ | ※※ |
| Karaismailoglu et al. | ※※ | ※ | ※ |
| Köken et al. | ※※ | ※ | ※※ |
| Sun et al. | ※※ | ※ | ※ |
| Sukur et al. | ※※ | ※ | ※※ |
| Ors et al. | ※※ | ※ | ※※ |
3.4 Sciatic nerve palsy
Eight articles (including a total of 542 hips)20,21,23,24,26–28,30 reported the rate of sciatic nerve palsy. No significant heterogeneity was observed (I2 = 0 %); therefore, the fixed-effects model was used. The pooled incidence of sciatic nerve palsy was 2.44 % (95 % CI: 0.86–4.01) (Fig. 2A). A subgroup analysis showed a pooled incidence of sciatic nerve palsy of 2.01 % (95 % CI: -0.10–4.12) for femoral resection greater than 3 cm and 2.74 % (95 % CI: 0.09–5.38) for femoral resection less than 3 cm (Fig. 2B). A subgroup analysis regarding the surgical approach showed a pooled incidence of sciatic nerve palsy of 2.52 % (95 % CI: 0.80–4.25) for the posterior approach and 2.00 % (95 % CI: -1.88–5.88) for the direct lateral (DL) approach (Fig. 2C).

3.5 Delayed union or nonunion
Eight articles (including a total of 547 hips)21–27,30 reported the rate of delayed union or nonunion. No significant heterogeneity was observed (I2 = 0 %); therefore, the fixed-effects model was used. The pooled incidence of delayed union or nonunion was 2.74 % (95 % CI: 1.11–4.37) (Fig. 3A). A subgroup analysis regarding the type of STO showed a pooled incidence of delayed union or nonunion of 2.68 % (95 % CI: 0.92–4.45) for transverse STO and 3.08 % (95 % CI: -1.11–7.27) for other osteotomies (Fig. 3B).

3.6 Dislocation
Nine articles (including a total of 653 hips)23–31 reported the rate of dislocation. No significant heterogeneity was observed (I2 = 0 %); therefore, the fixed-effects model was used. The pooled incidence of dislocation was 2.92 % (95 % CI: 1.63–4.20) (Fig. 4A). A subgroup analysis showed a pooled incidence of dislocation of 3.17 % (95 % CI: 1.70–4.65) for THA performed using the posterior approach (Fig. 4B). A subgroup analysis showed a pooled incidence of dislocation of 3.02 % (95 % CI: 0.94–5.09) for THA using a changeable neck stem (S-ROM or modular femoral revision stem) and 3.93 % (95 % CI: 1.41–6.45) for THA using a conical stem (Wagner cone stem) (Fig. 4C).

3.7 Intraoperative femoral fracture
Eight articles (including a total of 586 hips)22–24,26–28,30,31 reported the rate of intraoperative femoral fracture. No significant heterogeneity was observed (I2 = 11 %); therefore, the fixed-effects model was used. The pooled incidence of intraoperative femoral fracture was 2.19 % (95 % CI: 0.95–3.42) (Fig. 5A). A subgroup analysis showed a pooled incidence of intraoperative femoral fracture of 1.46 % (95 % CI: -0.10–3.01) for THA using a conical stem (Wagner cone stem) (Fig. 5B).

3.8 Infection
Six articles (including a total of 409 hips)22–24,26,27,30 reported the rate of infection. No significant heterogeneity was observed (I2 = 0 %); therefore, the fixed-effects model was used. The pooled incidence of infection was 3.11 % (95 % CI: 0.10–6.12) (Fig. 6).

3.9 HHS
Eight articles (including a total of 609 hips)21–24,26,27,30,31 reported the HHS. Significant heterogeneity was observed (I2 = 98 %); therefore, the random-effects model was used. Pooling of the data showed a mean HHS of 88.33 (95 % CI: 84.95–91.70) (Fig. 7).

3.10 Publication bias
A funnel plot of dislocations was used to evaluate publication bias. An asymmetry was exhibited in the funnel plot, which reflected publication bias (Fig. 8). However, only nine studies were included in the funnel plot. Therefore, the results should be interpreted with caution.

4 Discussion
The pooled incidence of sciatic nerve palsy, delayed union or nonunion, dislocation, intraoperative femoral fracture, and infection were 2.44 % (95 % CI: 0.86–4.01), 2.74 % (95 % CI: 1.11–4.37), 2.92 % (95 % CI: 1.63–4.20), 2.19 % (95 % CI: 0.95–3.42), and 3.11 % (95 % CI: 0.10–6.12), respectively. Pooling of the data showed a mean HHS of 88.33 (95 % CI: 84.95–91.70).
Sciatic nerve palsy is one of the serious complications. Its apparent risk factors are revision operations, female sex, significant lengthening of the extremity,32 and a previous femoral osteotomy.33 Our meta-analysis showed a pooled incidence of sciatic nerve palsy of 2.44 % (95 % CI: 0.86–4.01) for THA with STO. Even if THA with STO is performed for severe DDH, placing the acetabular component at the true acetabular height may result in hyperextension of the sciatic nerve, resulting in sciatic nerve palsy. A study by Eggli et al. showed that the occurrence of nerve damage was independent of limb length changes, with direct or indirect trauma being the most common cause.34 Consistent with the Eggli et al. study, our subgroup analysis comparing femoral bone resections of more than 3 cm with those of less than 3 cm found a similar incidence of sciatic nerve palsy between the two. We hypothesized that the posterior approach for THA with STO were less likely to cause sciatic nerve palsy because the sciatic nerve was easier to identify for anatomical reasons when using the approach. However, the subgroup analysis regarding the surgical approach showed a greater rate of sciatic nerve palsy in the posterior approach than that in the DL approach. İncesoy et al. reported that anatomical parameters associated with the shortening decision in severe DDH (Crowe type Ⅳ), operative leg length discrepancy, coronal position of neo-acetabulum, and axial position of neo-acetabulum are possible predictive factors of STO. They concluded that owing to these parameters, it may be possible to lower the technically demanding level of THA and avoid unnecessary repeated reduction attempts,35 which may reduce the incidence of sciatic nerve palsy.
Delayed union or nonunion is usually painful and leads to a poor prognosis.36 In the present study, the pooled incidence of delayed union or nonunion after THA with STO was 2.74 % (95 % CI: 1.11–4.37). Regarding the type of osteotomy, transverse STO was used in most of the studies included in this meta-analysis. The subanalysis showed a rate of delayed union or nonunion after THA with STO of 2.68 % (95 % CI: 0.92–4.45) for transverse STO and 3.08 % (95 % CI: –1.11–7.27) for other STO approaches. The advantages of transverse STO are the ease of the femoral rotation adjustment and overall simplicity of the technique.37 Conversely, the small contact area of the osteotomy site is considered a disadvantage for bone fusion. Notably, our meta-analysis revealed that transverse STO was not disadvantageous for bone fusion.
Dislocation is a serious complication of THA and may require revision surgery.38 The present meta-analysis showed a pooled incidence of dislocation after THA with STO of 2.92 % (95 % CI: 1.63–4.20). The causes of dislocation are multifactorial, and the surgical approach is one of the predictive factors.39,40 According to the subanalysis regarding the surgical approach, the dislocation rate after THA with STO was 3.17 % (95 % CI: 1.70–4.65) for the posterior approach. Although the posterior approach is generally considered to have higher dislocation rates, the approach was used in most of the studies in our meta-analysis. This may be due to the wider field of view provided by the approach, allowing easier manipulation of the femur. Several recent reports showed the results of THA with STO using the direct anterior approach (DAA).41 The DAA may reduce the risk of dislocation by preserving the posterior soft tissues of the hip joint, such as the posterior capsule and short external rotators.42 More outcome data of THA with STO using the DAA approach are expected as the procedure becomes more common. This will result in more published studies, thus allowing for future meta-analyses.
The orientation of the femoral component is another predictive factor of dislocation.43 The changeable neck system has been found to decrease the rate of dislocations after THA; this system allows for intraoperative control of the version of the femoral component. However, according to our subanalysis, the dislocation rate after THA with STO using a changeable neck system (S-ROM type and modular femoral revision stems) was relatively high.
One possible reason for the high frequency of intraoperative femoral fractures in THA for DDH is the characteristic narrow femoral canal.15 To reduce the risk of intraoperative fractures, the use of dedicated or custom stems is recommended. Another way to reduce the risk of intraoperative femoral fractures is to use a conical stem (Wagner cone stem). The present subanalysis showed a relatively low pooled incidence of intraoperative femoral fractures (1.46 %; 95 % CI: -0.10–3.01) in studies that reported using the conical stem (Wagner cone stem).
Surgical site infection, particularly periprosthetic joint infection (PJI), is a serious complication and significant burden due to increased morbidity, mortality, and disability. Patients with PJI often require multiple surgeries; therefore, infection prevention is very important.44 This meta-analysis showed a relatively high pooled incidence of infection (3.11 %; 95 % CI: 0.10–6.12). This infection rate may be related to the large surgical field and the long operative time due to the complexity of the procedure. Surgeons who perform this surgery must be attentive in preventing PJI.
Tahta et al. performed THA without STO in 77 patients with severe DDH (Crowe type III/IV) and reported a mean postoperative HHS of 82.7 (76–95), dislocation in three patients (3.8 %), and no sciatic nerve palsy in any patients.45 In comparison to their study, THA with STO had a lower dislocation rate (2.92 %) and a higher HHS score (88.33), although a higher rate of sciatic nerve palsy (2.44 %) than THA without STO. Therefore, surgeons must recognize that sciatic nerve palsy can occur with THA for DDH even when adding STO, and operations should be performed with careful attention to the sciatic nerve.
The present investigation is characterized by limitations which should be acknowledged. First, significant heterogeneity was observed between the included studies regarding the HHS (I2 = 98 %). This heterogeneity may be attributable to differences in various factors, such as the different demographic characteristics of patients. Second, unpublished trials and articles written in languages other than English were not included in this analysis, potentially leading to publication bias. Third, only 12 studies with relatively small sample sizes were included. Fourth, this study was a single-arm meta-analysis due to the lack of randomized controlled trial studies comparing THA with and without STO for severe DDH. These limitations may have reduced the quality of the evidence included in this meta-analysis, and more studies with larger sample sizes are needed to verify the stability and reliability of this study's results.
5 Conclusion
Twelve studies were included in this meta-analysis. The meta-analysis revealed that THA with STO for severe DDH resulted in low complication rates and good clinical scores.
CRediT authorship contribution statement
Tomonori Shigemura: Conceptualization, Methodology, Software, Data curation, Writing – original draft, Software, Validation. Yohei Yamamoto: Visualization, Investigation, Writing – review & editing. Yasuaki Murata: Supervision.
Patient consent
N/A.
Patient confidentiality and consent to publish
Not applicable.
Data availability
Data from this study is available from the corresponding author upon reasonable request.
Ethical statement
Ethics approval was not required due to the nature of the study.
Funding
None
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